Nutrition Therapy Promotes Overall Survival in Cachectic Cancer Patients through a New Proposed Chemical-Physical Pathway: The TiCaCONCO Trial (A Randomized Controlled Single-Blinded Trial)

Cancer threatens nutritional status, and many patients will become cachectic with a negative impact on prognosis. In the TiCaCo pilot trial, we showed positive effect of calorie matching Nutrition Therapy both morbidity mortality. We attempt to validate these results in TiCaCONCO trial. prospective, randomized, single-blinded, controlled were treated either intensive, individual biometric parameter-oriented dietary counseling (nutrition therapy or NT) for maximum period three months, regular (control CT), before during conventional cancer treatment. Sixty enrolled over two-year period, 30 receiving nutrition being controls. The primary endpoint was overall survival (OS). Overall at 12 months all 47% (14/30 patients) CT group median OS 45.5 weeks, 73% (22/30 NT that undefined (i.e., cannot be calculated, as >50% still alive end study) (p = 0.0378). difference exists when only male are analyzed, but is not observed female patients. Biophysical measurements performed 0, 3, men, differences between vs statistically significant body hydration 0.0400), fat mass 0.0480), total energy expenditure 0.0320), 0.0390). At 3 (end intervention), 73 ± 3% vs. 75 5%, 14 4% 19 2231 637 Kcal 2408 369 Kcal. women, 1.898), 0.9495), 0.2875) 0.6486). 74 2% 78 25 7% 29 19%, TEE 1657 297 1917 120 Therapy, based patient-specific biophysical parameters, including measurement metabolism by indirect calorimetry composition BIA, improves survival, least men. mechanism would increasing extra body, which necessary fight off cancer.